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MSC Cruises to South America

MSC Cruises South America cruise vacations provide guests with a chance to experience a South American cruise in Italian style and elegance. MSC Cruises to South America introduce travelers to the sights and sounds of the region, from the serenity of private beaches to the bustling city life of Rio de Janeiro, and provide excellent ships that rival the finest hotels in Italy. Onboard MSC Cruise Line, passengers can relax in on-deck swimming pools, enjoy fine Italian 7-course meals, or enjoy an evening show for the family. With all MSC Cruises to South America, kids sail free, making this a valuable family choice.

Showing 51-75 of 160 results
Roundtrip
7-Night South America Cruise
$929
43% Off List
MSC Cruises – MSC Armonia
19 Reviews
Departs Jan 18, 2025 from Itajaí, Brazil
Up to 3 deals including an Avoya Exclusive
Roundtrip
7-Night South America Cruise
$2,370
48% Off List
MSC Cruises – MSC Grandiosa
2 Reviews
Departs Jan 18, 2025 from Santos, Brazil
Up to 3 deals including an Avoya Exclusive
Roundtrip
6-Night South America Cruise
$750
44% Off List
MSC Cruises – MSC Orchestra
4 Reviews
Departs Jan 19, 2025 from Rio de Janeiro, Brazil
Up to 3 deals including an Avoya Exclusive
Roundtrip
7-Night South America Cruise
$894
45% Off List
MSC Cruises – MSC Seaview
5 Reviews
Departs Jan 19, 2025 from Santos, Brazil
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night South America Cruise
$1,392
MSC Cruises – MSC Splendida
9 Reviews
Departs Jan 20, 2025 from Buenos Aires, Argentina
Up to 1 deal including an Avoya Exclusive
Roundtrip
7-Night South America Cruise
$1,198
41% Off List
MSC Cruises – MSC Armonia
19 Reviews
Departs Jan 21, 2025 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
Roundtrip
7-Night South America Cruise
$799
44% Off List
MSC Cruises – MSC Grandiosa
2 Reviews
Departs Jan 22, 2025 from Maceió, Brazil
Up to 3 deals including an Avoya Exclusive
Roundtrip
7-Night South America Cruise
$725
MSC Cruises – MSC Splendida
9 Reviews
Departs Jan 24, 2025 from Santos, Brazil
Up to 1 deal including an Avoya Exclusive
Roundtrip
7-Night South America Cruise
$1,071
44% Off List
MSC Cruises – MSC Armonia
19 Reviews
Departs Jan 24, 2025 from Paranagua, Brazil
Up to 3 deals including an Avoya Exclusive
Roundtrip
9-Night South America Cruise
$1,806
34% Off List
MSC Cruises – MSC Poesia
29 Reviews
Departs Jan 24, 2025 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
Roundtrip
7-Night South America Cruise
$971
43% Off List
MSC Cruises – MSC Armonia
19 Reviews
Departs Jan 25, 2025 from Itajaí, Brazil
Up to 3 deals including an Avoya Exclusive
Roundtrip
8-Night South America Cruise
$1,377
39% Off List
MSC Cruises – MSC Orchestra
4 Reviews
Departs Jan 25, 2025 from Rio de Janeiro, Brazil
Up to 3 deals including an Avoya Exclusive
Roundtrip
9-Night South America Cruise
$1,838
40% Off List
MSC Cruises – MSC Poesia
29 Reviews
Departs Jan 25, 2025 from Montevideo, Uruguay
Up to 3 deals including an Avoya Exclusive
Roundtrip
7-Night South America Cruise
$2,259
48% Off List
MSC Cruises – MSC Grandiosa
2 Reviews
Departs Jan 25, 2025 from Santos, Brazil
Up to 3 deals including an Avoya Exclusive
Roundtrip
7-Night South America Cruise
$838
40% Off List
MSC Cruises – MSC Seaview
5 Reviews
Departs Jan 26, 2025 from Santos, Brazil
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night South America Cruise
$1,262
MSC Cruises – MSC Splendida
9 Reviews
Departs Jan 27, 2025 from Buenos Aires, Argentina
Up to 1 deal including an Avoya Exclusive
Roundtrip
7-Night South America Cruise
$964
45% Off List
MSC Cruises – MSC Grandiosa
2 Reviews
Departs Jan 28, 2025 from Salvador, Brazil
Up to 3 deals including an Avoya Exclusive
Roundtrip
7-Night South America Cruise
$769
44% Off List
MSC Cruises – MSC Grandiosa
2 Reviews
Departs Jan 29, 2025 from Maceió, Brazil
Up to 3 deals including an Avoya Exclusive
Roundtrip
7-Night South America Cruise
$1,068
MSC Cruises – MSC Splendida
9 Reviews
Departs Jan 30, 2025 from Itajaí, Brazil
Up to 1 deal including an Avoya Exclusive
Roundtrip
7-Night South America Cruise
$781
MSC Cruises – MSC Splendida
9 Reviews
Departs Jan 31, 2025 from Santos, Brazil
Up to 1 deal including an Avoya Exclusive
2-Night South America Cruise
$229
45% Off List
MSC Cruises – MSC Armonia
19 Reviews
Departs Feb 01, 2025 from Itajaí, Brazil
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night South America Cruise
$736
43% Off List
MSC Cruises – MSC Grandiosa
2 Reviews
Departs Feb 01, 2025 from Santos, Brazil
Up to 3 deals including an Avoya Exclusive
Roundtrip
6-Night South America Cruise
$600
43% Off List
MSC Cruises – MSC Orchestra
4 Reviews
Departs Feb 02, 2025 from Rio de Janeiro, Brazil
Up to 3 deals including an Avoya Exclusive
Roundtrip
7-Night South America Cruise
$766
40% Off List
MSC Cruises – MSC Seaview
5 Reviews
Departs Feb 02, 2025 from Santos, Brazil
Up to 2 deals including an Avoya Exclusive
Roundtrip
9-Night South America Cruise
$2,026
36% Off List
MSC Cruises – MSC Poesia
29 Reviews
Departs Feb 02, 2025 from Buenos Aires, Argentina
Up to 3 deals including an Avoya Exclusive
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