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MSC Cruises to Africa

MSC Cruises Africa cruises are diverse and exciting, exploring everything from ancient pyramids in Egypt to guided safaris in natural reserves. Onboard the MSC Sinfonia, which sails all of MSC Cruise line’s African Cruises, guests will enjoy distinct Italian style, comfortable accommodations, countless activities, and more. In addition, on all MSC Cruises to Africa, kids sail free!

Showing 101-125 of 165 results
Roundtrip
14-Night Africa Cruise
$1,729
MSC Cruises – MSC Opera
5 Reviews
Departs Dec 27, 2025 from Durban, South Africa
Up to 1 deal including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$1,074
MSC Cruises – MSC Musica
4 Reviews
Departs Dec 28, 2025 from Santa Cruz de Tenerife, Spain
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$623
MSC Cruises – MSC Musica
4 Reviews
Departs Jan 02, 2026 from Las Palmas, Spain
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$628
MSC Cruises – MSC Musica
4 Reviews
Departs Jan 03, 2026 from Funchal, Madeira Islands, Portugal
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$624
MSC Cruises – MSC Musica
4 Reviews
Departs Jan 04, 2026 from Santa Cruz de Tenerife, Spain
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$623
MSC Cruises – MSC Musica
4 Reviews
Departs Jan 09, 2026 from Las Palmas, Spain
Up to 2 deals including an Avoya Exclusive
Roundtrip
2-Night Africa Cruise
$229
MSC Cruises – MSC Opera
5 Reviews
Departs Jan 10, 2026 from Durban, South Africa
Up to 1 deal including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$628
MSC Cruises – MSC Musica
4 Reviews
Departs Jan 10, 2026 from Funchal, Madeira Islands, Portugal
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$624
MSC Cruises – MSC Musica
4 Reviews
Departs Jan 11, 2026 from Santa Cruz de Tenerife, Spain
Up to 2 deals including an Avoya Exclusive
Roundtrip
4-Night Africa Cruise
$399
MSC Cruises – MSC Opera
5 Reviews
Departs Jan 12, 2026 from Durban, South Africa
Up to 1 deal including an Avoya Exclusive
Roundtrip
3-Night Africa Cruise
$309
MSC Cruises – MSC Opera
5 Reviews
Departs Jan 16, 2026 from Durban, South Africa
Up to 1 deal including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$617
MSC Cruises – MSC Musica
4 Reviews
Departs Jan 16, 2026 from Las Palmas, Spain
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$628
MSC Cruises – MSC Musica
4 Reviews
Departs Jan 17, 2026 from Funchal, Madeira Islands, Portugal
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$624
MSC Cruises – MSC Musica
4 Reviews
Departs Jan 18, 2026 from Santa Cruz de Tenerife, Spain
Up to 2 deals including an Avoya Exclusive
Roundtrip
4-Night Africa Cruise
$389
MSC Cruises – MSC Opera
5 Reviews
Departs Jan 19, 2026 from Durban, South Africa
Up to 1 deal including an Avoya Exclusive
Roundtrip
3-Night Africa Cruise
$309
MSC Cruises – MSC Opera
5 Reviews
Departs Jan 23, 2026 from Durban, South Africa
Up to 1 deal including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$617
MSC Cruises – MSC Musica
4 Reviews
Departs Jan 23, 2026 from Las Palmas, Spain
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$628
MSC Cruises – MSC Musica
4 Reviews
Departs Jan 24, 2026 from Funchal, Madeira Islands, Portugal
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$624
MSC Cruises – MSC Musica
4 Reviews
Departs Jan 25, 2026 from Santa Cruz de Tenerife, Spain
Up to 2 deals including an Avoya Exclusive
Roundtrip
4-Night Africa Cruise
$389
MSC Cruises – MSC Opera
5 Reviews
Departs Jan 26, 2026 from Durban, South Africa
Up to 1 deal including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$713
MSC Cruises – MSC Musica
4 Reviews
Departs Jan 30, 2026 from Las Palmas, Spain
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$718
MSC Cruises – MSC Musica
4 Reviews
Departs Jan 31, 2026 from Funchal, Madeira Islands, Portugal
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$714
MSC Cruises – MSC Musica
4 Reviews
Departs Feb 01, 2026 from Santa Cruz de Tenerife, Spain
Up to 2 deals including an Avoya Exclusive
Roundtrip
4-Night Africa Cruise
$379
MSC Cruises – MSC Opera
5 Reviews
Departs Feb 02, 2026 from Durban, South Africa
Up to 1 deal including an Avoya Exclusive
Roundtrip
3-Night Africa Cruise
$309
MSC Cruises – MSC Opera
5 Reviews
Departs Feb 06, 2026 from Durban, South Africa
Up to 1 deal including an Avoya Exclusive
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