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MSC Cruises to Africa

MSC Cruises Africa cruises are diverse and exciting, exploring everything from ancient pyramids in Egypt to guided safaris in natural reserves. Onboard the MSC Sinfonia, which sails all of MSC Cruise line’s African Cruises, guests will enjoy distinct Italian style, comfortable accommodations, countless activities, and more. In addition, on all MSC Cruises to Africa, kids sail free!

Showing 76-100 of 165 results
14-Night Africa Cruise
$1,181
MSC Cruises – MSC Musica
4 Reviews
Departs Nov 02, 2025 from Genoa, Italy
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$623
MSC Cruises – MSC Musica
4 Reviews
Departs Nov 14, 2025 from Las Palmas, Spain
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$624
MSC Cruises – MSC Musica
4 Reviews
Departs Nov 16, 2025 from Santa Cruz de Tenerife, Spain
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$623
MSC Cruises – MSC Musica
4 Reviews
Departs Nov 21, 2025 from Las Palmas, Spain
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$638
MSC Cruises – MSC Musica
4 Reviews
Departs Nov 22, 2025 from Funchal, Madeira Islands, Portugal
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$624
MSC Cruises – MSC Musica
4 Reviews
Departs Nov 23, 2025 from Santa Cruz de Tenerife, Spain
Up to 2 deals including an Avoya Exclusive
Roundtrip
3-Night Africa Cruise
$319
MSC Cruises – MSC Opera
5 Reviews
Departs Nov 28, 2025 from Durban, South Africa
Up to 1 deal including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$623
MSC Cruises – MSC Musica
4 Reviews
Departs Nov 28, 2025 from Las Palmas, Spain
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$628
MSC Cruises – MSC Musica
4 Reviews
Departs Nov 29, 2025 from Funchal, Madeira Islands, Portugal
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$624
MSC Cruises – MSC Musica
4 Reviews
Departs Nov 30, 2025 from Santa Cruz de Tenerife, Spain
Up to 2 deals including an Avoya Exclusive
Roundtrip
4-Night Africa Cruise
$419
MSC Cruises – MSC Opera
5 Reviews
Departs Dec 01, 2025 from Durban, South Africa
Up to 1 deal including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$623
MSC Cruises – MSC Musica
4 Reviews
Departs Dec 05, 2025 from Las Palmas, Spain
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$624
MSC Cruises – MSC Musica
4 Reviews
Departs Dec 07, 2025 from Santa Cruz de Tenerife, Spain
Up to 2 deals including an Avoya Exclusive
Roundtrip
4-Night Africa Cruise
$429
MSC Cruises – MSC Opera
5 Reviews
Departs Dec 08, 2025 from Durban, South Africa
Up to 1 deal including an Avoya Exclusive
Roundtrip
3-Night Africa Cruise
$339
MSC Cruises – MSC Opera
5 Reviews
Departs Dec 12, 2025 from Durban, South Africa
Up to 1 deal including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$623
MSC Cruises – MSC Musica
4 Reviews
Departs Dec 12, 2025 from Las Palmas, Spain
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$624
MSC Cruises – MSC Musica
4 Reviews
Departs Dec 14, 2025 from Santa Cruz de Tenerife, Spain
Up to 2 deals including an Avoya Exclusive
Roundtrip
4-Night Africa Cruise
$429
MSC Cruises – MSC Opera
5 Reviews
Departs Dec 15, 2025 from Durban, South Africa
Up to 1 deal including an Avoya Exclusive
Roundtrip
3-Night Africa Cruise
$379
MSC Cruises – MSC Opera
5 Reviews
Departs Dec 19, 2025 from Durban, South Africa
Up to 1 deal including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$983
MSC Cruises – MSC Musica
4 Reviews
Departs Dec 19, 2025 from Las Palmas, Spain
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$988
MSC Cruises – MSC Musica
4 Reviews
Departs Dec 20, 2025 from Funchal, Madeira Islands, Portugal
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$984
MSC Cruises – MSC Musica
4 Reviews
Departs Dec 21, 2025 from Santa Cruz de Tenerife, Spain
Up to 2 deals including an Avoya Exclusive
Roundtrip
5-Night Africa Cruise
$659
MSC Cruises – MSC Opera
5 Reviews
Departs Dec 22, 2025 from Durban, South Africa
Up to 1 deal including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$1,073
MSC Cruises – MSC Musica
4 Reviews
Departs Dec 26, 2025 from Las Palmas, Spain
Up to 2 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$1,078
MSC Cruises – MSC Musica
4 Reviews
Departs Dec 27, 2025 from Funchal, Madeira Islands, Portugal
Up to 2 deals including an Avoya Exclusive
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