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MSC Cruises to Africa

MSC Cruises Africa cruises are diverse and exciting, exploring everything from ancient pyramids in Egypt to guided safaris in natural reserves. Onboard the MSC Sinfonia, which sails all of MSC Cruise line’s African Cruises, guests will enjoy distinct Italian style, comfortable accommodations, countless activities, and more. In addition, on all MSC Cruises to Africa, kids sail free!

Showing 51-75 of 165 results
Roundtrip
4-Night Africa Cruise
$439
44% Off List
MSC Cruises – MSC Musica
4 Reviews
Departs Feb 17, 2025 from Durban, South Africa
Up to 3 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$677
32% Off List
MSC Cruises – MSC Opera
5 Reviews
Departs Feb 17, 2025 from Las Palmas, Spain
Up to 3 deals including an Avoya Exclusive
Roundtrip
8-Night Africa Cruise
$629
21% Off List
MSC Cruises – MSC Opera
5 Reviews
Departs Feb 20, 2025 from Funchal, Madeira Islands, Portugal
Up to 3 deals including an Avoya Exclusive
Roundtrip
3-Night Africa Cruise
$304
42% Off List
MSC Cruises – MSC Musica
4 Reviews
Departs Feb 21, 2025 from Durban, South Africa
Up to 3 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$569
28% Off List
MSC Cruises – MSC Opera
5 Reviews
Departs Feb 23, 2025 from Santa Cruz de Tenerife, Spain
Up to 3 deals including an Avoya Exclusive
Roundtrip
4-Night Africa Cruise
$439
44% Off List
MSC Cruises – MSC Musica
4 Reviews
Departs Feb 24, 2025 from Durban, South Africa
Up to 3 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$627
34% Off List
MSC Cruises – MSC Opera
5 Reviews
Departs Feb 24, 2025 from Las Palmas, Spain
Up to 3 deals including an Avoya Exclusive
Roundtrip
6-Night Africa Cruise
$812
33% Off List
MSC Cruises – MSC Opera
5 Reviews
Departs Feb 28, 2025 from Funchal, Madeira Islands, Portugal
Up to 3 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$746
28% Off List
MSC Cruises – MSC Opera
5 Reviews
Departs Mar 02, 2025 from Santa Cruz de Tenerife, Spain
Up to 3 deals including an Avoya Exclusive
Roundtrip
4-Night Africa Cruise
$439
44% Off List
MSC Cruises – MSC Musica
4 Reviews
Departs Mar 03, 2025 from Durban, South Africa
Up to 3 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$747
34% Off List
MSC Cruises – MSC Opera
5 Reviews
Departs Mar 03, 2025 from Las Palmas, Spain
Up to 3 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$941
40% Off List
MSC Cruises – MSC Opera
5 Reviews
Departs Mar 06, 2025 from Funchal, Madeira Islands, Portugal
Up to 3 deals including an Avoya Exclusive
3-Night Africa Cruise
$314
43% Off List
MSC Cruises – MSC Musica
4 Reviews
Departs Mar 09, 2025 from Durban, South Africa
Up to 3 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$696
26% Off List
MSC Cruises – MSC Opera
5 Reviews
Departs Mar 09, 2025 from Santa Cruz de Tenerife, Spain
Up to 3 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$777
35% Off List
MSC Cruises – MSC Opera
5 Reviews
Departs Mar 10, 2025 from Las Palmas, Spain
Up to 3 deals including an Avoya Exclusive
Roundtrip
7-Night Africa Cruise
$759
30% Off List
MSC Cruises – MSC Opera
5 Reviews
Departs Mar 16, 2025 from Santa Cruz de Tenerife, Spain
Up to 3 deals including an Avoya Exclusive
10-Night Africa Cruise
$1,015
32% Off List
MSC Cruises – MSC Opera
5 Reviews
Departs Mar 17, 2025 from Las Palmas, Spain
Up to 3 deals including an Avoya Exclusive
17-Night Africa Cruise
$1,988
30% Off List
MSC Cruises – MSC Opera
5 Reviews
Departs Mar 17, 2025 from Las Palmas, Spain
Up to 3 deals including an Avoya Exclusive
7-Night Africa Cruise
$1,041
41% Off List
MSC Cruises – MSC Opera
5 Reviews
Departs Mar 20, 2025 from Funchal, Madeira Islands, Portugal
Up to 2 deals
14-Night Africa Cruise
$1,641
30% Off List
MSC Cruises – MSC Opera
5 Reviews
Departs Mar 20, 2025 from Funchal, Madeira Islands, Portugal
Up to 3 deals including an Avoya Exclusive
6-Night Africa Cruise
$519
MSC Cruises – MSC Opera
5 Reviews
Departs Mar 23, 2025 from Santa Cruz de Tenerife, Spain
11-Night Africa Cruise
$953
21% Off List
MSC Cruises – MSC Opera
5 Reviews
Departs Mar 23, 2025 from Santa Cruz de Tenerife, Spain
Up to 3 deals including an Avoya Exclusive
9-Night Africa Cruise
$1,074
28% Off List
MSC Cruises – MSC Opera
5 Reviews
Departs Mar 23, 2025 from Santa Cruz de Tenerife, Spain
Up to 3 deals including an Avoya Exclusive
7-Night Africa Cruise
$777
37% Off List
MSC Cruises – MSC Opera
5 Reviews
Departs Mar 27, 2025 from Valencia, Spain
Up to 3 deals including an Avoya Exclusive
5-Night Africa Cruise
$409
MSC Cruises – MSC Opera
5 Reviews
Departs Mar 29, 2025 from Rome (Civitavecchia), Italy
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